Hemophilia A and hemophilia B are inherited in an X-linked pattern. Sudden effects of hemophilia include sudden pain, swelling, and hot joints in the knees, elbows, hips, and possibly shoulders. Common symptoms are blood in the stool, blood in the urine, internal bleeding, or swollen joints. Hemophilia occurs in approximately 1 in 5,000 male births. Currently, approximately 20,000 men in the United States are living with this condition. Hemophilia A is about four times more common than hemophilia B, and about half of those affected have a severe form. Hemophilia affects people of all racial and ethnic groups. Say no to plagiarism. Get a tailor-made essay on 'Why violent video games should not be banned'? Get the original essay Hemophilia has been called a 'royal disease'. Indeed, the hemophilia gene was transmitted by Queen Victoria, who became Queen of England in 1837, to the ruling families of Russia, Spain and Germany. Queen Victoria's gene for hemophilia was caused by a spontaneous mutation. Hemophilia is a genetic, but rare, condition that does not allow blood to clot properly, which in turn can make it difficult to clot. to stop the bleeding. This is often caused by an abnormality in the DNA that causes substances called clotting factors to function abnormally. It is primarily a hereditary disorder. The inheritance of hemophilia C follows an autosomal recessive pattern. is not present on a sex chromosome and the disease can affect both sexes equally. For example, if a woman inherits an affected X chromosome, she becomes a carrier of hemophilia. She can then pass it on to her children. A female carrier may sometimes have symptoms of hemophilia, also called mild hemophilia. The affected chromone All they may suffer from is heavy menstrual bleeding. The risk of suffering from hemophilia depends on whether parents are present. If they = are hemophiliacs or carriers. If the father has hemophilia and the mother is a carrier, the sons will likely be at risk of having hemophilia. Currently, there is no cure for hemophilia. But scientists are still trying to find a cure. They believe the answer lies in gene therapy. The chemical “directions” of blood clotting are found on a certain gene in every cell in the body. So, men can suffer from a disease like hemophilia if they inherit an affected X chromosome that has a mutation in the factor VIII or factor IX gene. Women can also have hemophilia, but it is much rarer. In such cases, both X chromosomes are affected or one is affected and the other is missing or inactive. Keep in mind: this is just a sample. Get a personalized article from our expert writers now. Get a personalized trial Gene therapy helps patients with hemophilia. During the clotting process, blood cells become trapped in a fibrous mesh formed with the help of clotting factor IX. Gene therapy involves transferring DNA into body tissues. It specifically targets cells in the body that are not passed on to the person's children. Researchers at the Institute are studying the possibility of treating this disease with gene therapy. Their strategy involves creating mesenchymal stem cells, a type of adult stem cell, so that they produce high levels of..