Although Cushing's syndrome is rare, some symptoms include: skinny arms and legs, severe fatigue and muscle weakness, high blood pressure, high blood sugar (blood glucose level high), easy bruising, upper body obesity. (most commonly on the face), a round, red, or full face (moon face), acne or skin infections, purple marks (1/2 inch or more in width) on the skin of the abdomen, thighs or breasts, and thin skin. Some symptoms vary by gender. Men may experience symptoms, such as decreased or absent sexual desire or even impotence, while women may experience excessive hair growth on the face, neck, chest, abdomen and lower back. thighs. Women's menstrual cycles may also become irregular or stop altogether. Just because a patient has one or two of the symptoms above does not mean they have Cushing's syndrome, but it may mean they need to see a doctor for further testing. Cushing's syndrome occurs when body tissues are exposed to high levels of cortisol for too long. Cortisol is produced by the zona fasciculata of the adrenal cortex of the adrenal gland and ...