Blow Fill Seal PackagingBlow Fill Seal is a unique packaging technique that can produce liquid filling containers of small and large size and shape. The BFS technique began in the United States in the 1960s, but over the past two decades it has become more common and practical within the pharmaceutical industry, and is now widely considered the superior form of treatment aseptic by various drug regulatory agencies, including the United States Food and Drug Administration (FDA) in the area of ​​pharmaceutical and healthcare product packaging. The concept behind BFS is that a container is formed, filled and sealed in a continuous process without human intervention, in a closed sterile area inside a machine. Thus, this technology can be useful in aseptic manufacturing processes and in the aseptic manufacturing of sterile pharmaceutical liquid dosage forms. The BFS technique is cheaper than other common techniques and saves a lot of time and labor. Blow seal technology reduces personnel intervention, making it a more robust method for the aseptic preparation of pharmaceutical products and sterile packaging. BFS is used for filling bottles of parenteral preparations and infusions, eye drops and inhalation products. Typically, plastic containers are made from polyethylene and polypropylene. Polypropylene is more commonly used to form autoclave sterilized containers because polypropylene has greater thermostability. BFS is a multi-step process. Each step is unique in itself. Initially, the pharmaceutical grade plastic resin is hot extruded vertically using a circular groove, to form a suspended tube called a Parison. This extruded tube is then enclosed in a two-part mold and the tube is cut above the mold. After......the middle of the paper......d to its final thermal condition. Another feature provided by reconfiguring the initially outwardly domed panels to an inwardly folded position is that each panel causes a fairly large volume change. thereby decreasing the number of panels required compared to that provided by panels that are initially configured to be concave. Reducing the number of panels or the proportion of area covered by such panels means that greater support can be given to any label applied to the container on such panels. These and other features and advantages of the present invention will become apparent to those skilled in the art. in the art by considering the following detailed description of preferred embodiments illustrating the best embodiment of the invention as currently perceived. The detailed description refers in particular to the appended drawings.