Today, supply chains play an important role in determining the position of companies in their competitive environment. In this research, a three-tier multi-product supply chain was modeled to minimize the total cost. Then, the mathematical model was analyzed by considering disruptions based on three deferred sales policies: backorders, lost sales, and outsourcing. Model solved efficiently by MATLAB software. The results show that the algorithm proposed in this research can neutralize the effect of disturbances and result in a significant reduction in the total system cost. The model is useful in helping decision-makers take an active approach to preserving business advantages when disruptions occur in the supply chain. Say no to plagiarism. Get a Tailored Essay on “Why Violent Video Games Should Not Be Banned”?Get an Original EssayThe survival of organizations is due to their ability to provide better outlets in a wider range, at lower costs than their competitors, to perform faster and deliver the desired results (in various aspects, such as quality, performance, cost, innovation and delivery). Achieving these results depends on the organization's ability to manage the flow of materials, information and money within and outside the organization. This flow is known as the supply chain. In today's competitive market, supply chain coordination (SCC) is of great importance. In the event of a lack of coordination, SC members optimize their own decisions independently. Supply chains can be complex and long and involve many different trading partners, and their problems are inevitable. Failure to resolve these issues will lead to customer dissatisfaction and lost sales and impose many costs on organizations. World-class companies owe many of their successes to supply chain management, which is why supply chain has become a popular management discourse in recent decades. Since supply chain loops are independent economic entities, creating a mechanism capable of coordinating the activities and objectives of these entities in order to optimize the overall performance of the system is a key issue in management of the supply chain. Typically, traditional supply chain research focused on decision making under ideal conditions, where demand was defined and the producer had complete market information; but in the real world, complete market information is rarely available and obtaining demand distributions can be difficult or impossible. In a dynamic and complex supply chain environment, uncertainty is considered a significant concern. Demand uncertainty is also a significant problem in the scientific and industrial world. These demand uncertainties have posed major challenges to supply chain management, leading to a reduction in real revenues. In order to account for uncertainty and its effects, it is necessary to pay attention to the sources of uncertainty, which are disruptions or interruptions in all parts of the supply chain. Many studies have been carried out on the main area of ​​this research, the chain..