IntroductionMultiple sclerosis (MS) is a debilitating autoimmune disease. The central nervous system (CNS) is attacked by the immune system; creating damage that interrupts proper signaling in the nerves, spinal cord and brain (Frankel and James, 2011). Inhibiting the development of this disease is crucial for maintaining quality of life and fatigue in people with MS. Much research has been conducted on the effect of various exercise training programs and their benefits for MS (Motl and Gosney, 2008, Krupp, 2003, Chen, Fan, Hu, Yang, and Li, 2013). Balance, aerobic, and strength training have been the focus of most researchers' attention; sparking interest in the most effective mode of training to improve quality of life and reduce fatigue. It is essential to examine and compare the effectiveness of a variety of exercise programs, because if the training is followed effectively, it can significantly improve the quality of life and fatigue of people with MS. There is a need to better understand the effects of exercise on people with MS. pay attention to two specific gaps. First, knowledge about which type of exercise (balance, aerobic, or strength training) is most effective is limited. Because exercise is beneficial for improving fatigue and quality of life, it is essential to examine which mode of exercise provides the best results (Motl, 2008). Second, there is limited knowledge about the effectiveness of exercise programs that can be performed in a non-clinical setting (i.e., community or recreational center). It is important to examine nonclinical settings because of their realistic application for MS patients. To address these gaps, it is essential to focus on the mode and context of exercise. MS patients suffer from fatigue, which makes walking difficult for people with multiple sclerosis. Advances in Physiotherapy, 9(3), 136-143. Pantea, C., Sîrbu, E. and Pantea, S. (2011). Effects of physical activity on functional and cardiorespiratory capacity in multiple sclerosis. Timisoara Physical Education & Rehabilitation, 4(7), 29-35. Pilutti, LA, Lelli, DA, Paulseth, JE, Crome, M., Jiang, S., Rathbone, MP and Hicks, AL (2011). Effects of 12 weeks of assisted treadmill training on functional capacity and quality of life in progressive multiple sclerosis: a pilot study. Archives of Physical Medicine and Rehabilitation, 92(1), 31-36.Tarakci, E., Yeldan, I., Huseyinsinoglu, B.E., Zenginler, Y., and Eraksoy, M. (2013). Group exercise training for balance, functional status, spasticity, fatigue and quality of life in multiple sclerosis: a randomized controlled trial. Clinical rehabilitation, 27(9), 813-823.