Beta-thalassemia: the fatal genetic disease that destroys the lives of children and adolescents. Beta thalassemia major (BT) is an astringent hemolytic anemia that has a unique genetic deformity. It has more than 200 mutations; most of them are very rare and affect almost 20 different alleles in the chromosome. About 3% of the world's population carries this gene. As scary as the word is, beta thalassemia comes from thalassa meaning sea and haima meaning blood. In simple terms, it is called “Mediterranean” anemia or “Cooley’s anemia.” You can guess that the disease mainly occurs in the Middle East region or Southwest Asia because of its common name, which is completely accurate. Beta thalassemia is a rare disease passed from parent to child. There is a detailed mechanism for how this can happen. Basically, once an offspring chromosome has a defect in both of its alleles, it is a beta-globin mutation; he or she is likely to have a severe form of beta thalassemia, called beta thalassemia major. This would significantly affect the way the child develops and thinks, and this is accompanied by various conditions that can cause imbalances in the body system, causing premature death at a very early age. According to the National Health of Rare Disease, one of the first symptoms of this disease is a general feeling of ill health (malaise), weakness, pale complexion, stomach upset (dyspepsia), and heart palpitations. Affected infants may have a yellowish appearance of the skin, eyes, and mucous membranes (jaundice); leg ulcers; an abnormally enlarged liver, hepatomegaly (April 2013, p 6). If the victim receives proper treatment, they could see their teenage years. You may ask yourself, why is it important to study this d...... middle of paper ...... if it is not treated with accordingly. A common treatment for an individual, especially in North Africa, who suffers from this disease, microcytic anemia, is mainly eating certain herbs in an attempt to increase the body's iron intake. However, it does not work for everyone due to the severity level of the disease. beta thalassemia, further medical treatment is mainly carried out with specific medical prescriptions, to increase iron level, others to increase iron absorption to form normal red blood cell. thalassemia.[Internet]. April 2012 [cited November 17, 2013]; 26(0 1):S12-S15. Available at: http://ehis.ebscohost.com.ezproxy.uosc.edu/eds/detail?vid=3&sid=5567aaa2-a958-45d2-aa60e8b390862281%40sessionmgr11&hid=105&bdata=JnNpdGU9ZWRzLWxpdmU%3d#db=edselp& AN=S 0268960X1270005X