Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. Tuberculosis bacilli have lived in symbiosis with humanity since time immemorial. In the Western world, the clinical characteristics and transmissibility of tuberculosis were known before 1000 BC). (1)] Tuberculosis has remained a major public health problem since the dawn of civilization. Over the past 15 years, the fight against tuberculosis has made good progress globally, but an estimated 9.6 million people contracted tuberculosis worldwide in 2014: 5.4 million men, 3 .2 million women and 1.0 million children and 1.5 million died from tuberculosis (3). Of the estimated 1.0 million cases of tuberculosis among children worldwide, 75% occur in the 22 most affected countries (4). In countries with low morbidity, childhood tuberculosis represents 95% of cases among children. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get an original essayOne of the major challenges of childhood tuberculosis is making an accurate diagnosis. In children Although serum-based antibody tests offer the advantages of easy and rapid sample collection, none of the currently available serological tests are sufficiently sensitive or specific for clinical use. Detection of interferon gamma (g) production by sensitized mononuclear cells (TSPOT) or whole blood (interferon gamma (g) release assay) upon stimulation with M. tuberculosis ESAT-specific antigens -6 and CFP-10 is an alternative to TCT. 15]. Interferon gamma (g) release assays have not been shown to have major advantages over TST in terms of sensitivity or specificity and are more expensive; the advantages are that they do not require a second patient visit and reduce the chance of human error in the measurement. [16-19] In 2010, the Centers for Disease Control and Prevention (CDC) updated its guidelines for testing for tuberculosis infection, concluding that IGRAs "may be used in place of a skin test at tuberculin in all situations in which the CDC recommends the tuberculin skin test as an aid in the diagnosis of M. tuberculosis infection” [20,21] Keep in mind: this is just a sample. a custom article now written by our expert writers.Get a custom essayCurrently, the major role of these tests is probably intended to detect latent tuberculosis in countries where tuberculosis is not endemic. But they could potentially play a role in detecting TB in HIV-infected or malnourished children, severe TB and other forms of immunosuppression for which TST is poorly effective; however, this requires further research. In this part of our country, childhood tuberculosis is highly endemic and the majority of children suffer from malnutrition. Considering certain conditions such as difficult microbiological confirmation, rapid progression from latent to active and severe form of tuberculosis in children, the majority of tuberculosis children are malnourished and studies evaluating the performance of IGRA in children children are rare, especially in this region, I would like to study the diagnostic value of interferon gamma release (IGRA) tests in children with tuberculosis.