Aluminum is present in large quantities in the earth's crust, mainly in the form of insoluble aluminum silicates. It is rare in the human body that contains only 30 to 50 mg of this metal. This is due to the insolubility of aluminum, the presence of a barrier in the gastrointestinal tract against soluble forms of aluminum, and the ability of the kidneys to efficiently excrete aluminum in healthy people. health. Aluminum is present in foods, in the form of additives, tea. rich in aluminum and drinking water treated with aluminum to eliminate organic residues. Aluminum is also present in large quantities in medications such as antacids or aspirin products. Most of the aluminum in plasma is bound to transferrin, an iron-transporting protein. Aluminum accumulates in areas of the brain with the highest concentration of transferrin receptors, such as the cortex, hippocampus, and amygdala; the same areas vulnerable to the development of Alzheimer's disease. The distribution of aluminum in the brain reflects which neurons have the greatest iron requirements. Entry of aluminum into the brain is mediated by transferrin. The question of aluminum as a cause of Alzheimer's disease is controversial. In special circumstances such as kidney failure and massive exposure to aluminum in certain professions, aluminum can cause brain pathology similar to Alzheimer's disease. However, there is no definitive evidence for the role of this metal in the etiology or development of Alzheimer's disease. Some cases of presenile Alzheimer's disease (occurring before the age of 65) are hereditary and are associated with a mutation in the beta-amyloid precursor. APP protein (APP) gene involved in Alzheimer's disease. Elderly cases of Alzheimer's disease...... middle of article...... relationship between Alzheimer's disease and aluminum in drinking water: CN Martyn, C Osmond, JA Edwardson , DJP Barker… - The Lancet, 1989 Absence of aluminum in Neuritic plaque nuclei in Alzheimer's disease: JP Landsberg, B McDonald… - 1992 - nature. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: study by laser microprobe (LAMMA): PF Good, DP Perl, LM Bierer… - Annals of[HTML] Metabolism and possible effects of aluminum on health.from nih.gov PO Ganrot - Environmental Health Perspectives, 1986 - ncbi.nlm.nih.gov Brain aluminum concentration in dialysis encephalopathy: JR McDermott, AI Smith, MK Ward, IS Parkinson… - The Lancet, 1978 - ElsevierAluminum as a risk factor in Alzheimer's disease, with emphasis on drinking water: from antic-cancer.fr TP Flaten - Brain Research Bulletin, 2001 - Elsevier