“Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, leading to hypertension portal disease and end-stage liver disease (ESLD) progressing to cirrhosis and ultimately leading to decompensated liver disease. »Say no to plagiarism. Get a custom essay on “Why Violent Video Games Should Not Be Banned”?Get the original essay Cirrhosis is one of the leading causes of death in Asia, ranking as the tenth leading cause of death in the United States -United, while it is the leading cause of death in the world. 12th most common cause. Medical treatments likely to slow the progression from compensated cirrhosis to decompensated cirrhosis are in the research phase. Liver transplantation, however, is the only option in a selected subgroup of patients with ESLD and HCC. Vitamin D is also known to have multiple extraskeletal functions. The liver is the main organ involved in the synthesis and metabolism of vitamin D after the kidneys. 25-hydroxylation occurs in the liver, converting it to the active form. Various experimental studies have demonstrated an increase in the prevalence of vitamin D deficiency and its insufficiency in patients with chronic liver disease and cirrhosis. It is often noted that sometimes even in the absence of cirrhosis, a vitamin D deficiency can be detected in the majority of subjects. However, subjects with cirrhosis had vitamin D deficiency. (Various studies indicate that vitamin D deficiency is linked to the pathophysiology of cirrhosis. Some studies have proven (to some extent) that vitamin D levels are inversely correlated with those of liver dysfunction as evidenced by the Child Pugh score and MELD score. Furthermore, vitamin D deficiency has been implicated in an increased risk of overall mortality and infections in patients with cirrhosis. Recently, a study revealed that an increase in MELD score observed in transplant cases was associated with vitamin D deficiency. The liver's storage organ for fat-soluble vitamins, vitamin B12, is one of them. Patients with chronic liver disease or cirrhosis, vitamin B12 is often elevated in serum. However, its normal values ​​have also been found in some patients, especially in cases of long-standing portal cirrhosis. Keep in mind: this is just a sample. Get a personalized article from our expert writers now. Get a Personalized Test Some studies have indicated that high serum vitamin B12 levels can be a sign of serious and life-threatening illness. Very high levels of vitamin B12 have been observed in patients with advanced stages of viral liver cirrhosis. There is only one report demonstrating the association of vitamin B12 level with disease severity and mortality related to hepatitis B virus infection in the short term. No reports have evaluated vitamin B12 dynamics in chronic viral hepatitis. Accordingly, the present study aimed to evaluate the relationship between serum vitamin B12, disease severity and long-term prognosis of liver disease in patients with cirrhosis...