Introduction to thesis md 4002: Grant AitkenIs cannabis consumption an independent risk factor for the development of psychosis?Cannabis or marijuana is an annual flowering plant of the Cannabaceae family, containing 3 major species C. Indica C.Sativa and C.Ruderalis. The first two species are of major interest to those discussing cannabis use due to their widespread illicit use. Cannabis has been cultivated since at least 6000 BCE in what is now China. However, the cannabis plant was most likely used as a textile when it was used as an intoxicant, which is less clear [1]. The first indisputable reference to the psychoactive uses of cannabis comes from Herodotus's “Researches” in 450 BCE where he describes that “the Scythians threw cannabis on the stones, producing smoke which they inhaled”[2]. Cannabis, when used recreationally, is usually smoked. , sprayed or eaten to achieve the desired effect. The main active ingredients are THC (Tetrahydrocannabinol) and CBD (cannabidiol). However, there are over 400 individual compounds residing in the said plant [3]. THC, as the main psychoactive component, acts on CB1 receptors throughout the body, but primarily in the brain [4] to inhibit adenylate cyclase [5]. It is through the effects on adenylate cyclase that THC indirectly increases the release of dopamine in the striatum. This is responsible for the effect experienced by the user and these results suggest that THC could potentially be addictive [6]. Despite widespread ritual use in the ancient world, the British government had no official reports on the effects of cannabis use until 1894. Indian Hemp Commission [7]'. Conclusion on the effects of marijuana consumption on 3 distinct reasons, Physical, Mental and Moral (Morali...... middle of the article ......independent of the production methods. Hypotheses on the relationship between the Cannabis and Psychotic Illness These 4 shortlisted hypotheses are included here so that subsequent evidence discussed in studies can refer to these concise hypotheses to better identify whether concepts describing the relationship between cannabis and schizophrenia are correct.[45] .1 and that there is a causal link between cannabis and schizophrenia.[45]2 Cannabis worsens the prognosis in patients who already suffer from a psychotic illness.[45]3 Cannabis use does not only precipitates psychosis in vulnerable individuals.[45]4 Cannabis is simply more commonly used in psychotic individuals, perhaps as a form of self-psychosis.[45] At the end of this review we will have. a clear idea of ​​which hypothesis provides the best answer to the review question: is cannabis an independent risk factor for psychosis ??