Table of contentsIntroduction……………………………………………………………………..Context……………… … ………………………………………………………Previous work…………………………………………………………………… Results and discussion……………………………………………………………Future work………………………………………………………… … …………..…Experimental procedures………………………………………………………………References……………………………………… … ……………………………………IntroductionThe synthesis of molecules is very important in the development of natural products used in medicine today.1 However, the current synthesis method has many problems that conflict with numerous synthesis methods. The guidelines of the 12 principles of green chemistry are potentially dangerous.2 The proposed research plan includes the formation of a salt by allylation followed by the Aza-Claisen rearrangement which has shown success with benzothiazole. Ultimately, this research aims to eliminate these costly and ineffective factors and create a more productive and safer plan for obtaining the natural products used in medicine today. Azoles are 5-membered cyclic heterocycles containing one nitrogen atom and at least one other non-carbon atom. .Azole derivatives are most commonly found in medications intended to treat fungal infections. Some very common examples are fluconazole, miconazole, and ketoconazole, which work by inhibiting cytochrome P450-dependent enzymes that are part of the synthesis of ergosterol within the cell membrane. Azoles can also be found in medications which treat AIDS, cancer and acid reflux. The synthesis of azole derivatives is a key step in the acquisition of the compounds used in these drugs; and as azoles are widely used in today's society, it is important to make this process as efficient as possible. In recent decades, people in our society have become much more aware of middle of paper... ...recent advances in carbon-carbon bond forming reactions involving homoenolates generated by NHC catalysis. Nair, V.; Vellalath, S.; Babu, BP Chem. Soc. Rev.2008, 37, 2691-2698.11. Addition of N-heterocyclic carbenes to imines: phenoxide-assisted deprotonation of an imidazolium moiety and generation of imine-derived Breslow intermediates. Simonovic, S.; Frison, J.-C.; Koyuncu, H.; Whitwood, A.C.; Douthwaite, RE Org. Lett. 2009, 11, 245-247.12. Anti-plasmodium activity of imidazolium and triazolium salts, bioorganic and medicinal chemistry. Jason Z. Vlahakis, Carmen Lazar, Ian E. Crandall, Walter A. Szareka. 2010, 18, 6184-6196.13. 13C NMR spectroscopic determination of ligand donor strength using N-heterocyclic palladium(II) carbene complexes. Han Vinh Huynh*, Yuan Han, Ramasamy Jothibasu and Jie An Yang. 2009, 5395-5405.