Skin cancer is a preeminent global public health problem. Over the past three decades, more people have had skin cancer than the combined incidence of breast, prostate, lung and colon cancers. Skin cancer is generally classified into two distinct categories, namely malignant melanoma and non-melanocytic cutaneous carcinoma (NMSC). NMSC is much more common than melanoma, as basal cell carcinoma (BCC) accounts for the majority of cases, approximately 80-85%, and has a low rate of metastasis, while squamous cell carcinoma (SCC) has a higher tendency to metastasize and mortality than BCC. In contrast, melanoma represents less than 1% of skin cancers, but is responsible for 80% of all deaths linked to skin carcinomas. An estimated five-year survival rate in melanoma patients has been detected to be around 98%, but it drops to 62% when the disease reaches the lymph nodes and 18% when the disease metastasizes to distant organs. Say no to plagiarism. Get a tailor-made essay on 'Why violent video games should not be banned'? Get the original essay DNA is the molecular target of many drugs used in the treatment of cancer, and has been shown to be of powerful inducers of cell death. They act via a different mechanism based on the chemistry of damage to the cell by which they initiate apoptosis. Over the past decade, specific DNA lesions triggering apoptosis have been identified. These include O6-methylguanine, base N-alkylations, bulky DNA adducts, DNA cross-links, and DNA double-strand breaks (DSBs). Potentially lethal events in the cell are DNA double-strand breaks (DSBs) that prevent replication and transcription, cause cell cycle arrest, and activate pro-apoptotic genes such as BAX (BCL2-associated protein , PUMA (p53 positively regulated apoptosis modulator). ) and the FAS receptor ends in apoptosis. Anticancer agents that target DNA are among the most effective agents in clinical use and have produced significant increases in survival in cancer patients, but unfortunately, they are extremely toxic. The development of effective and treatment-free side effects in healthcare is the new direction. to fight against cancer treatment. Bioactive ingredients from plant secondary metabolites have been shown to be potential in this regard, as they act differently on cancer cells only, without altering normal cells. Phytochemicals exhibit a wide range of effects, which act on multiple targets, such as antioxidants, anti-inflammatory, and anti-angiogenic to prevent, prevent, delay, or cure cancer. Essential oils, concentrated hydrophobic liquids, have long been used in traditional medicine for their specific aromas but also as flavoring agents in foods. The lipophilic nature of these Essential Oils allows them to easily cross cell membranes and reach the interior of the cell. The majority of components in essential oils are terpenoids of a chemical nature, most often monoterpenes. Alpha pinene (AP) is an organic compound of the monoterpene class, one of the two isomers of pinene. It is found in the oils of many species of many conifers, notably pine, and it is also found in the essential oil of rosemary. PA isolated from pine trees exhibited strong antioxidant and anti-inflammatory properties. In this study, we have375).