Literature review: Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”?Get the original essay Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, affecting 6 to 10% of women worldwide (Kumarnarendran et al. 2018). PCOS represents a major health burden for women with economic costs in America estimated at $4.36 billion per year (Arentz et al 2017). Diagnostic criteria include the presence of androgen excess, oligomenorrhea, and evidence of polycystic ovaries on ultrasound (Kumarnarendran et al 2018). Its diagnosis is based on the presence of at least two of the following criteria: hyperandrogenism, determined by the presence of excess testosterone characterized by hirsutism; ovarian dysfunction characterized by oligoamenorrhea and chronic anovulation; and the detection of a specific morphology of polycystic ovaries (Pasquali, 2018). Although traditionally viewed as a reproductive disorder, PCOS is now emerging as a lifelong metabolic disorder, with evidence of increased prevalence of obesity, insulin resistance and metabolic syndrome (Kumarnarendran et al 2018 ). Evidence-based restorative treatments should emphasize a multidisciplinary approach to PCOS, but as usual pharmaceutical treatment tends toward a single manifestation, it may be counter-evident from time to time and is often associated with reactions. Additionally, women with PCOS have expressed a strong need for substitution treatment, as approximately 2 in 5 women with this condition prefer herbs (Arentz et al 2014a, 2014b). Herbal medicines contain biologically active chemicals that may alter reproductive endocrinology in women with PCOS (Arentz et al 2014a, 2014b). Paeoniae Radix is ​​the dried root of Paeonia lactiflora, called peony in English and Shakuyaku in Japanese and is frequently used. in traditional Japanese medicine and was first described in China in 200 BC and plant products were used in ancient Greece for their medicinal benefits (Shimada-Takaura et al 2018). Within the Paeonia lactiflora group, white peony root is produced in southern China and red peony root is produced in northern China and is used for different remedies (Zhu et al 2014). White peony root has been used for abdominal pain, diarrhea, blood deficiency and unpredictable menstruation etc. while red peony root has been basically used for blood stasis, gynecological problems, diseases cardiovascular, etc. (Zhu et al 2014). White peony has played a vital role in the conventional Chinese solution and is believed to influence human androgen levels in vitro and also in a report found in American Diary of Chinese Prescription, Takeuchi et al described the effects of the paeoniflorin, a compound found in white peony that prevented the creation of testosterone and advanced the movement of aromatase, which converts testosterone into estrogen (Grant and Ramasamy 2012). Although only P. Lactiflora has two other root types available depending on its geographic location, Paeoniae is not limited to a single species. It was found that in two regular but different types of peonies, namely P. lactiflora and P. veitchii, there are normal mixtures of flavonoids, hydrolyzable tannins (polyphenols) and monoterpene glycosides, but their phytochemical bioavailability differs (Parker et al 2016). The confirmation suggests that.