NSHIP BETWEEN GUT MICROBIOTA AND TYPE 2 DIABETESIntroductionDiabetes is a metabolic disease that causes high blood pressure in a person. There are two types of diabetes, type 1 and type 2. Type 1 is the loss of insulin-producing cells, leading to insulin deficiency. Type 2 diabetes is where the person is resistant to insulin. Insulin is a peptide hormone that causes cells to absorb the different glucoses they need. Type 2 diabetes is the most common endocrine disease worldwide. The associated metagenome-wide study focused on a study based on determining type 2 diabetes and its relationship with gut microbes using deep sequencing of gut microbes. The study included 345 Chinese individuals who were used to help find relationships. 60,000 markers associated with type 2 diabetes have been used and linked to type 2 diabetes. Gut microbes are living organisms that live in the intestine and digestive tract. Patients with type 2 diabetes were characterized by a moderate degree of gut microbial symbiosis. Symbiosis is an interaction between different microbial organisms. There are different types of symbiosis such as mutalist, parasitic and communitarian. The abundance of butyrate-producing bacteria as well as opportunistic pathogens were also determined. An enrichment of microbial functions due to sulfate reduction and resistance to oxidative stress was noted. Other studies have also been carried out with the addition of individuals to the study. Gut microbial markers may be useful in classifying type 2 diabetes. Type 2 diabetes has become a major disorder that has significantly affected the world. Genome-wide association studies show that type 2 diabetes may be involved in other genes.... ... middle of paper ...... an important role and significant impact on how the body responds to other organisms and disease. The study was biased in that only one ethnic group was tested on the Chinese, perhaps the suggestion of conducting the same study on other ethnic groups could be explored and studied which would see if the ethnic group has an impact on intestinal microbes. and whether a change in this area would have an effect on type 2 diabetic patients. The study made great use of all the different orthologs, categories and many different databases, while also compiling their own references and taxonomic indexes. While this was great, arbitrage to too many databases can confuse the areas you plan to look at, this is important. to stay on topic and evaluate appropriately. The study left many other avenues open and much more research can be done to better understand their findings..