First century Rome, Cornelius Celsus was the first to describe inflammation as consisting of pain, heat, redness, and swelling. Then, in the 19th century, German physician Rudolf Virchow suggested the link between inflammation and various chronic diseases(1). Inflammation can be divided into acute inflammation and chronic inflammation. Acute inflammation is a type of immune response while chronic inflammation results in severe disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin are used to treat inflammation, but at the same time cause devastating side effects. According to the Medilexicon Medical Dictionary, inflammation is a fundamental pathological process that consists of a dynamic complex of histologically apparent cytological changes, cellular infiltration, and release of mediators that occur in affected blood vessels and adjacent tissues (2 ). Inflammatory responses to foreign substances such as bacteria or, in some cases, internally produced substances (3). It is part of the body's immune response. Acute inflammation appears quickly and quickly becomes severe within hours and days. This involves three processes. First, there is an increase in blood flow due to the dilation of the arterioles supplying the injured area, causing that area to turn red. Second, there is increased permeability of capillaries, which allows more fluids and blood proteins to pass into the interstitial spaces. This led to edema (swelling). Finally, neutrophils and some macrophages migrate from blood vessels into tissues. Neutrophils bind to the endothelium of blood vessels due to the cell adhesion molecule (CAM) found on the surface of neutrophils and endothelial cells in injured tissues. Sometimes this led to the formation of pus (4...... middle of article......hington.edu/conj/inflammation/acuteinflam.htm (accessed).5. University of Washington. Chronic Inflammation . http://courses.washington.edu/conj/inflammation/chronicinflam.htm (accessed).6. University of Albany, State University of New York and AINS http://www.albany.edu/faculty/ cs812. /bio366/Cyclooxygenase_ppt.pdf (accessed).7 Monash University How aspirin works http://www.aspree.org/AUS/aspree-content/aspirin/how-aspirin-works.aspx (accessed).8 Thea Morris, Melanie Stables, Adrian Hobbs, Patricia de Souza, Paul Colville-Nash, Tim Warner, Justine Newson, Geoffrey Bellingan and Derek W. Gilroy 2 Effects of low-dose aspirin on acute inflammatory responses in humans1. 1 August 2009; vol. 183 (no. 3): 2089-2096.9.. ).